Diabetic Pregnancy and Maternal High-Fat Diet Impair Mitochondrial Dynamism in the Developing Fetal Rat Heart by Sex-Specific Mechanisms

Diabetic Pregnancy and Maternal High-Fat Diet Impair Mitochondrial Dynamism in the Developing Fetal Rat Heart by Sex-Specific Mechanisms

Infants born to diabetic or obese mothers are at greater risk of heart disease at birth and throughout life, but prevention is hindered because underlying mechanisms remain poorly understood. Using a rat model, we showed that prenatal exposure to maternal diabetes and a high-fat diet caused diastoli...

Full description

Bibliographic Details
Main Authors:	Tricia D. Larsen, Kyle H. Sabey, Alexis J. Knutson, Tyler C. T. Gandy, Eli J. Louwagie, Lothar Lauterboeck, Kennedy S. Mdaki, Michelle L. Baack
Format:	Article
Language:	English
Published:	MDPI AG 2019-06-01
Series:	International Journal of Molecular Sciences
Subjects:	maternal diabetes maternal high-fat diet cardiovascular disease mitochondrial dynamism sex-specific mechanisms of the developmental origins of health and disease (DOHaD)
Online Access:	https://www.mdpi.com/1422-0067/20/12/3090

Similar Items

Etude du lien entre infertilité, obésité et stress oxydant à partir d'un modèle animal et d'une étude cas-témoins chez l'Homme
by: Leveille, Pauline Clémence Elisa
Published: (2013)

The Impact of Maternal High-Fat Diet on Bone Microarchitecture in Offspring
by: Emma J. Buckels, et al.
Published: (2021-08-01)

Maternal Sedentary Behavior and Physical Activity across Pregnancy and Early Childhood Motor Development
by: Melissa A. Jones, et al.
Published: (2021-06-01)

Maternal-Fetal Inflammation in the Placenta and the Developmental Origins of Health and Disease
by: Jeffery A. Goldstein, et al.
Published: (2020-11-01)

Human Milk Oligosaccharide Concentrations and Infant Intakes Are Associated with Maternal Overweight and Obesity and Predict Infant Growth
by: Jessica L. Saben, et al.
Published: (2021-01-01)

Maternal selenium deficiency in mice promotes sex‐specific changes to urine flow and renal expression of mitochondrial proteins in adult offspring
by: Elliott S. Neal, et al.
Published: (2021-03-01)

Editorial: Decoding the Fetal Circadian System and Its Role in Adult Sickness and Health: Melatonin, a Dark History
by: Claudia Torres-Farfan, et al.
Published: (2020-07-01)

Application of the Nutrient-Rich Food Index 9.3 and the Dietary Inflammatory Index for Assessing Maternal Dietary Quality in Japan: A Single-Center Birth Cohort Study
by: Chihiro Imai, et al.
Published: (2021-08-01)

Relationships between Prenatal Distress and Infant Body Mass Index in the First Year of Life in a Lower-Middle Income Country
by: Ann-Sophie Therrien, et al.
Published: (2020-10-01)

Environmental Exposures around Conception: Developmental Pathways Leading to Lifetime Disease Risk
by: Tom P. Fleming, et al.
Published: (2021-09-01)

Translational insights on developmental origins of metabolic syndrome: Focus on fructose consumption
by: Wei-Chia Lee, et al.
Published: (2018-04-01)

Prenatal Nicotine Exposure Induces Low Birthweight and Hyperinsulinemia in Male Rats
by: Takahiro Nemoto, et al.
Published: (2021-06-01)

Origens desenvolvimentistas da saúde e da doença (DOHaD) Developmental origins of health and disease (DOHaD)
by: Patrícia P. Silveira, et al.
Published: (2007-12-01)

Preventing Developmental Origins of Cardiovascular Disease: Hydrogen Sulfide as a Potential Target?
by: Chien-Ning Hsu, et al.
Published: (2021-02-01)

Higher maternal BMI early in pregnancy is associated with overweight and obesity in young adult offspring in Thailand
by: Sakaewan Ounjaijean, et al.
Published: (2021-04-01)

Placental mitochondrial DNA content is associated with childhood intelligence
by: Esmée M. Bijnens, et al.
Published: (2019-11-01)

Mother or Father: Who Is in the Front Line? Mechanisms Underlying the Non-Genomic Transmission of Obesity/Diabetes via the Maternal or the Paternal Line
by: Bernard Portha, et al.
Published: (2019-01-01)

Gasotransmitters for the Therapeutic Prevention of Hypertension and Kidney Disease
by: Chien-Ning Hsu, et al.
Published: (2021-07-01)

Early-Life Programming and Reprogramming of Adult Kidney Disease and Hypertension: The Interplay between Maternal Nutrition and Oxidative Stress
by: Chien-Ning Hsu, et al.
Published: (2020-05-01)

Disease Prevention in the Age of Convergence - the Need for a Wider, Long Ranging and Collaborative Vision
by: Susan L. Prescott
Published: (2014-01-01)

Preventive Aspects of Early Resveratrol Supplementation in Cardiovascular and Kidney Disease of Developmental Origins
by: Chien-Ning Hsu, et al.
Published: (2021-04-01)

Spatiotemporal Small Non-coding RNAs Expressed in the Germline as an Early Biomarker of Testicular Toxicity and Transgenerational Effects Caused by Prenatal Exposure to Nanosized Particles
by: Satoshi Yokota, et al.
Published: (2021-06-01)

Altered Gut Microbiota and Its Metabolites in Hypertension of Developmental Origins: Exploring Differences between Fructose and Antibiotics Exposure
by: Chien-Ning Hsu, et al.
Published: (2021-03-01)

Maternal High Fat Diet and Diabetes Disrupts Transcriptomic Pathways That Regulate Cardiac Metabolism and Cell Fate in Newborn Rat Hearts
by: Claudia C. Preston, et al.
Published: (2020-09-01)

The path ahead: From global pandemic to health promotion
by: Amara Finch, et al.
Published: (2021-03-01)

Developmental Programming and Reprogramming of Hypertension and Kidney Disease: Impact of Tryptophan Metabolism
by: Chien-Ning Hsu, et al.
Published: (2020-11-01)

Sex-Specific Alterations in Cardiac DNA Methylation in Adult Mice by Perinatal Lead Exposure
by: Laurie K. Svoboda, et al.
Published: (2021-01-01)

Early Origins of Hypertension: Should Prevention Start Before Birth Using Natural Antioxidants?
by: Chien-Ning Hsu, et al.
Published: (2020-10-01)

Portable HEPA filter air cleaner use during pregnancy and children’s behavior problem scores: a secondary analysis of the UGAAR randomized controlled trial
by: Undarmaa Enkhbat, et al.
Published: (2021-07-01)

The Role of Offspring Genotype-By-Sex Interactions, Independently of Environmental Cues, on the Phenotype Traits of an Obese Swine Model
by: Ana Heras-Molina, et al.
Published: (2020-12-01)

Mitochondrial DNA Copy Number and Developmental Origins of Health and Disease (DOHaD)
by: Hisanori Fukunaga
Published: (2021-06-01)

Perinatal Resveratrol Therapy Prevents Hypertension Programmed by Maternal Chronic Kidney Disease in Adult Male Offspring: Implications of the Gut Microbiome and Their Metabolites
by: Chien-Ning Hsu, et al.
Published: (2020-12-01)

Editorial: Exposure to Endocrine-Disrupting Chemicals and Cardiometabolic Disease: A Developmental Origins Approach
by: Wei Perng, et al.
Published: (2019-10-01)

Precision Nutrition and Childhood Obesity: A Scoping Review
by: Yue Wu, et al.
Published: (2020-06-01)

Maternal N-Acetylcysteine Therapy Prevents Hypertension in Spontaneously Hypertensive Rat Offspring: Implications of Hydrogen Sulfide-Generating Pathway and Gut Microbiota
by: Chien-Ning Hsu, et al.
Published: (2020-09-01)

Prenatal and postnatal determinants in shaping offspring’s microbiome in the first 1000 days: study protocol and preliminary results at one month of life
by: Benedetta Raspini, et al.
Published: (2020-04-01)

Maternal Melatonin Therapy Attenuates Methyl-Donor Diet-Induced Programmed Hypertension in Male Adult Rat Offspring
by: You-Lin Tain, et al.
Published: (2018-10-01)

Maternal Resveratrol Therapy Protects Male Rat Offspring against Programmed Hypertension Induced by TCDD and Dexamethasone Exposures: Is It Relevant to Aryl Hydrocarbon Receptor?
by: Chien-Ning Hsu, et al.
Published: (2018-08-01)

Maternal Melatonin Therapy Attenuated Maternal High-Fructose Combined with Post-Weaning High-Salt Diets-Induced Hypertension in Adult Male Rat Offspring
by: You-Lin Tain, et al.
Published: (2018-04-01)

Animal Models for DOHaD Research: Focus on Hypertension of Developmental Origins
by: Chien-Ning Hsu, et al.
Published: (2021-05-01)