Synthetic regulatory RNAs selectively suppress the progression of bladder cancer

Synthetic regulatory RNAs selectively suppress the progression of bladder cancer

Abstract The traditional treatment for cancer is lack of specificity and efficacy. Modular synthetic regulatory RNAs, such as inhibitive RNA (iRNA) and active RNA (aRNA), may overcome these limitations. Here, we synthesize a new iRNA to bind the upstream activating sequence (UAS) of a minimal promot...

Full description

Bibliographic Details
Main Authors: Chengle Zhuang, Xinbo Huang, Changshui Zhuang, Xiaomin Luo, Xiaowei Zhang, Zhiming Cai, Yaoting Gui
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Bladder cancer
Human telomerase reverse transcriptase
Artificial miRNA
GAL4
Online Access:http://link.springer.com/article/10.1186/s13046-017-0626-x

Internet

http://link.springer.com/article/10.1186/s13046-017-0626-x

Similar Items