Dose-resolved serial synchrotron and XFEL structures of radiation-sensitive metalloproteins

Dose-resolved serial synchrotron and XFEL structures of radiation-sensitive metalloproteins

An approach is demonstrated to obtain, in a sample- and time-efficient manner, multiple dose-resolved crystal structures from room-temperature protein microcrystals using identical fixed-target supports at both synchrotrons and X-ray free-electron lasers (XFELs). This approach allows direct comparis...

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Bibliographic Details
Main Authors: Ali Ebrahim, Tadeo Moreno-Chicano, Martin V. Appleby, Amanda K. Chaplin, John H. Beale, Darren A. Sherrell, Helen M. E. Duyvesteyn, Shigeki Owada, Kensuke Tono, Hiroshi Sugimoto, Richard W. Strange, Jonathan A. R. Worrall, Danny Axford, Robin L. Owen, Michael A. Hough
Format: Article
Language:English
Published: International Union of Crystallography 2019-07-01
Series:IUCrJ
Subjects:
XFELs
microcrystals
serial femtosecond crystallography
serial synchrotron crystallography
serial millisecond crystallography
fixed targets
heme peroxidase
metalloproteins
radiation damage
Online Access:http://scripts.iucr.org/cgi-bin/paper?S2052252519003956

Internet

http://scripts.iucr.org/cgi-bin/paper?S2052252519003956

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