A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium

A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium

Salmonella Typhimurium replicates within host phagocytes. Here, the authors show that a known psychoactive drug (metergoline) inhibits growth of the pathogen in macrophages, disrupts the proton motive force at the bacterial cytoplasmic membrane, and extends animal survival during systemic infection.

Bibliographic Details
Main Authors: Michael J. Ellis, Caressa N. Tsai, Jarrod W. Johnson, Shawn French, Wael Elhenawy, Steffen Porwollik, Helene Andrews-Polymenis, Michael McClelland, Jakob Magolan, Brian K. Coombes, Eric D. Brown
Format: Article
Language:English
Published: Nature Publishing Group 2019-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-08190-x

Internet

https://doi.org/10.1038/s41467-018-08190-x

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