Fission yeast 26S proteasome mutants are multi-drug resistant due to stabilization of the Pap1 transcription factor.

Fission yeast 26S proteasome mutants are multi-drug resistant due to stabilization of the Pap1 transcription factor.

Here we report the result of a genetic screen for mutants resistant to the microtubule poison methyl benzimidazol-2-yl carbamate (MBC) that were also temperature sensitive for growth. In total the isolated mutants were distributed in ten complementation groups. Cloning experiments revealed that most...

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Bibliographic Details
Main Authors: Mary Penney, Itaru Samejima, Caroline R Wilkinson, Christopher J McInerny, Søs G Mathiassen, Mairi Wallace, Takashi Toda, Rasmus Hartmann-Petersen, Colin Gordon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3507774?pdf=render

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http://europepmc.org/articles/PMC3507774?pdf=render

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