Single-cell characterization of macrophages in glioblastoma reveals MARCO as a mesenchymal pro-tumor marker

Single-cell characterization of macrophages in glioblastoma reveals MARCO as a mesenchymal pro-tumor marker

Abstract Background Macrophages are the most common infiltrating immune cells in gliomas and play a wide variety of pro-tumor and anti-tumor roles. However, the different subpopulations of macrophages and their effects on the tumor microenvironment remain poorly understood. Methods We combined new a...

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Bibliographic Details
Main Authors: Andrew X. Chen, Robyn D. Gartrell, Junfei Zhao, Pavan S. Upadhyayula, Wenting Zhao, Jinzhou Yuan, Hanna E. Minns, Athanassios Dovas, Jeffrey N. Bruce, Anna Lasorella, Antonio Iavarone, Peter Canoll, Peter A. Sims, Raul Rabadan
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Genome Medicine
Subjects:
Glioblastoma
Single-cell RNA-seq
Cancer immunotherapy
Macrophages
Online Access:https://doi.org/10.1186/s13073-021-00906-x

Internet

https://doi.org/10.1186/s13073-021-00906-x

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