Theoretical insights into catalytic mechanism of protein arginine methyltransferase 1.

Theoretical insights into catalytic mechanism of protein arginine methyltransferase 1.

Protein arginine methyltransferase 1 (PRMT1), the major arginine asymmetric dimethylation enzyme in mammals, is emerging as a potential drug target for cancer and cardiovascular disease. Understanding the catalytic mechanism of PRMT1 will facilitate inhibitor design. However, detailed mechanisms of...

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Bibliographic Details
Main Authors: Ruihan Zhang, Xin Li, Zhongjie Liang, Kongkai Zhu, Junyan Lu, Xiangqian Kong, Sisheng Ouyang, Lin Li, Yujun George Zheng, Cheng Luo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3748068?pdf=render

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http://europepmc.org/articles/PMC3748068?pdf=render

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