The GABAA antagonist bicuculline attenuates progesterone-induced memory impairments in middle-aged ovariectomized rats

The GABAA antagonist bicuculline attenuates progesterone-induced memory impairments in middle-aged ovariectomized rats

In women, high levels of natural progesterone have been associated with detrimental cognitive effects via the maternal amnesia phenomenon as well as in controlled experiments. In aged ovariectomized (Ovx) rats, progesterone has been shown to impair cognition and impact the GABAergic system in cognit...

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Bibliographic Details
Main Authors: B. Blair Braden, Melissa L. Kingston, Elizabeth eWhitton, Courtney N. Lavery, Candy W.S. Tsang, Heather Allyson Bimonte-Nelson
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
Aging
Bicuculline
Memory
Menopause
Progesterone
GABA
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00149/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00149/full

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