Acetylcholine Delays Atrial Activation to Facilitate Atrial Fibrillation

Acetylcholine Delays Atrial Activation to Facilitate Atrial Fibrillation

BackgroundAcetylcholine (ACh) shortens action potential duration (APD) in human atria. APD shortening facilitates atrial fibrillation (AF) by reducing the wavelength for reentry. However, the influence of ACh on electrical conduction in human atria and its contribution to AF are unclear, particularl...

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Bibliographic Details
Main Authors: Jason D. Bayer, Bastiaan J. Boukens, Sébastien P. J. Krul, Caroline H. Roney, Antoine H. G. Driessen, Wouter R. Berger, Nicoline W. E. van den Berg, Arie O. Verkerk, Edward J. Vigmond, Ruben Coronel, Joris R. de Groot
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Physiology
Subjects:
atria
fibrillation
acetylcholine
conduction
fibrosis
computational modeling
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.01105/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.01105/full

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