Clinical Application of Next-Generation Sequencing of Plasma Cell-Free DNA for Genotyping Untreated Advanced Non-Small Cell Lung Cancer

Clinical Application of Next-Generation Sequencing of Plasma Cell-Free DNA for Genotyping Untreated Advanced Non-Small Cell Lung Cancer

Background: Analysis of circulating tumor DNA (ctDNA) has remarkable potential as a non-invasive lung cancer molecular diagnostic method. This prospective study addressed the clinical value of a targeted-gene amplicon-based plasma next-generation sequencing (NGS) assay to detect actionable mutations...

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Bibliographic Details
Main Authors: Maria Gabriela O. Fernandes, Natália Cruz-Martins, Conceição Souto Moura, Susana Guimarães, Joana Pereira Reis, Ana Justino, Maria João Pina, Adriana Magalhães, Henrique Queiroga, José Carlos Machado, Venceslau Hespanhol, José Luis Costa
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
circulating tumor DNA (ctDNA)
cell-free DNA (cfDNA)
next generation sequencing (NGS)
lung adenocarcinoma
liquid biopsy
genotyping
Online Access:https://www.mdpi.com/2072-6694/13/11/2707

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https://www.mdpi.com/2072-6694/13/11/2707

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