Inefficient Nef-mediated downmodulation of CD3 and MHC-I correlates with loss of CD4+T cells in natural SIV infection.

Inefficient Nef-mediated downmodulation of CD3 and MHC-I correlates with loss of CD4+T cells in natural SIV infection.

Recent data suggest that Nef-mediated downmodulation of TCR-CD3 may protect SIVsmm-infected sooty mangabeys (SMs) against the loss of CD4+ T cells. However, the mechanisms underlying this protective effect remain unclear. To further assess the role of Nef in nonpathogenic SIV infection, we cloned ne...

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Bibliographic Details
Main Authors: Michael Schindler, Jan Schmökel, Anke Specht, Hui Li, Jan Münch, Mohammad Khalid, Donald L Sodora, Beatrice H Hahn, Guido Silvestri, Frank Kirchhoff
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-07-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2444047?pdf=render

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http://europepmc.org/articles/PMC2444047?pdf=render

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