MTD–CoMSIA modelling of HMG-CoA reductase inhibitors

MTD–CoMSIA modelling of HMG-CoA reductase inhibitors

The 3D quantitative structure–activity relationship for a series of hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitors based on the pyrrolylethyl-tetrahydropyranone scaffold was examined using the Minimal Topological Difference (MTD) method and comparative molecular similarity index analysis (...

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Bibliographic Details
Main Authors: DANIEL M. DUDA-SEIMAN, SPERANŢA AVRAM, SILVIA MANCAŞ, VALENTIN CAREJA, CORINA DUDA-SEIMAN, MIHAI V. PUTZ, DAN CIUBOTARIU
Format: Article
Language:English
Published: Serbian Chemical Society 2011-01-01
Series:Journal of the Serbian Chemical Society
Subjects:
statins
molecular modelling
correlations
3D-quantitative structure–biological activity
Online Access:http://www.shd.org.rs/JSCS/Vol76/No1/09_4798_4102.pdf

Internet

http://www.shd.org.rs/JSCS/Vol76/No1/09_4798_4102.pdf

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