PPAR gamma agonist leriglitazone improves frataxin-loss impairments in cellular and animal models of Friedreich Ataxia

PPAR gamma agonist leriglitazone improves frataxin-loss impairments in cellular and animal models of Friedreich Ataxia

Friedreich ataxia (FRDA), the most common autosomal recessive ataxia, is characterized by degeneration of the large sensory neurons and spinocerebellar tracts, cardiomyopathy, and increased incidence in diabetes. The underlying pathophysiological mechanism of FRDA, driven by a significantly decrease...

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Bibliographic Details
Main Authors: Laura Rodríguez-Pascau, Elena Britti, Pablo Calap-Quintana, Yi Na Dong, Cristina Vergara, Fabien Delaspre, Marta Medina-Carbonero, Jordi Tamarit, Federico V. Pallardó, Pilar Gonzalez-Cabo, Joaquim Ros, David R. Lynch, Marc Martinell, Pilar Pizcueta
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Neurobiology of Disease
Subjects:
Friedreich Ataxia
Frataxin
Neurodegeneration
Mitochondrial function
Dorsal root ganglia neurons
Cardiomyocytes
Online Access:http://www.sciencedirect.com/science/article/pii/S096999612030437X

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http://www.sciencedirect.com/science/article/pii/S096999612030437X

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