In Vivo Evidence for Voltage-Gated Sodium Channel Expression in Carcinomas and Potentiation of Metastasis

In Vivo Evidence for Voltage-Gated Sodium Channel Expression in Carcinomas and Potentiation of Metastasis

A wide body of evidence suggests that voltage-gated sodium channels (VGSCs) are expressed de novo in several human carcinomas where channel activity promotes a variety of cellular behaviours integral to the metastatic cascade. These include directional motility (including galvanotaxis), pH balance,...

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Bibliographic Details
Main Authors: Mustafa B. A. Djamgoz, Scott P. Fraser, William J. Brackenbury
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cancers
Subjects:
metastasis
voltage-gated sodium channel
embryonic splice
imaging
electrolytes
xenografts
epidemiology
Online Access:https://www.mdpi.com/2072-6694/11/11/1675

Internet

https://www.mdpi.com/2072-6694/11/11/1675

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