Sox2 acts as a rheostat of epithelial to mesenchymal transition during neural crest development

Sox2 acts as a rheostat of epithelial to mesenchymal transition during neural crest development

Precise control of self-renewal and differentiation of progenitor cells into the cranial neural crest (CNC) pool ensures proper head development, guided by signaling pathways such as BMPs, FGFs, Shh and Notch. Here, we show that murine Sox2 plays an essential role in controlling progenitor cell beh...

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Bibliographic Details
Main Authors: Nikolaos eMandalos, Muriel eRhinn, Zoraide eGranchi, Ioannis eKarampelas, Thimios eMitsiadis, Aris eEconomides, Pascal eDolle, Eumorphia eRemboutsika
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-09-01
Series:Frontiers in Physiology
Subjects:
Head
Stem Cells
Tooth
Craniofacial Development
neural progenitors
Sox genes
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00345/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00345/full

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