Posttranslationally modified progesterone receptors direct ligand-specific expression of breast cancer stem cell-associated gene programs

Posttranslationally modified progesterone receptors direct ligand-specific expression of breast cancer stem cell-associated gene programs

Abstract Background Estrogen and progesterone are potent breast mitogens. In addition to steroid hormones, multiple signaling pathways input to estrogen receptor (ER) and progesterone receptor (PR) actions via posttranslational events. Protein kinases commonly activated in breast cancers phosphoryla...

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Bibliographic Details
Main Authors: Todd P. Knutson, Thu H. Truong, Shihong Ma, Nicholas J. Brady, Megan E. Sullivan, Ganesh Raj, Kathryn L. Schwertfeger, Carol A. Lange
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Journal of Hematology & Oncology
Subjects:
Progesterone receptor (PR)
Phosphorylation
ERK/MAP kinase (MAPK)
SUMOylation
Antiprogestin
Onapristone
Online Access:http://link.springer.com/article/10.1186/s13045-017-0462-7

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http://link.springer.com/article/10.1186/s13045-017-0462-7

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