Skeletal muscle growth hormone receptor signaling regulates basal, but not fasting-induced, lipid oxidation.

Skeletal muscle growth hormone receptor signaling regulates basal, but not fasting-induced, lipid oxidation.

Growth hormone (GH) stimulates whole-body lipid oxidation, but its regulation of muscle lipid oxidation is not clearly defined. Mice with a skeletal muscle-specific knockout of the GH receptor (mGHRKO model) are protected from high fat diet (HFD)-induced insulin resistance and display increased whol...

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Bibliographic Details
Main Authors: Archana Vijayakumar, YingJie Wu, Nicholas J Buffin, Xiaosong Li, Hui Sun, Ronald E Gordon, Shoshana Yakar, Derek LeRoith
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3443095?pdf=render

Internet

http://europepmc.org/articles/PMC3443095?pdf=render

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