Quinacrine Induces Nucleolar Stress in Treatment-Refractory Ovarian Cancer Cell Lines

Quinacrine Induces Nucleolar Stress in Treatment-Refractory Ovarian Cancer Cell Lines

A considerable subset of gynecologic cancer patients experience disease recurrence or acquired resistance, which contributes to high mortality rates in ovarian cancer (OC). Our prior studies showed that quinacrine (QC), an antimalarial drug, enhanced chemotherapy sensitivity in treatment-refractory...

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Bibliographic Details
Main Authors: Derek B. Oien, Upasana Ray, Christopher L. Pathoulas, Ling Jin, Prabhu Thirusangu, Deokbeom Jung, Joseph E. Kumka, Yinan Xiao, Sayantani Sarkar Bhattacharya, Dennis Montoya, Jeremy Chien, Viji Shridhar
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cancers
Subjects:
quinacrine
ribosomal biogenesis
nucleolar stress
nucleostemin
chemotherapy resistance
ovarian cancer
Online Access:https://www.mdpi.com/2072-6694/13/18/4645

Internet

https://www.mdpi.com/2072-6694/13/18/4645

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