Single cell eQTL analysis identifies cell type-specific genetic control of gene expression in fibroblasts and reprogrammed induced pluripotent stem cells

Single cell eQTL analysis identifies cell type-specific genetic control of gene expression in fibroblasts and reprogrammed induced pluripotent stem cells

Abstract Background The discovery that somatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) has provided a foundation for in vitro human disease modelling, drug development and population genetics studies. Gene expression plays a critical role in complex disease risk and thera...

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Bibliographic Details
Main Authors: Drew Neavin, Quan Nguyen, Maciej S. Daniszewski, Helena H. Liang, Han Sheng Chiu, Yong Kiat Wee, Anne Senabouth, Samuel W. Lukowski, Duncan E. Crombie, Grace E. Lidgerwood, Damián Hernández, James C. Vickers, Anthony L. Cook, Nathan J. Palpant, Alice Pébay, Alex W. Hewitt, Joseph E. Powell
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Genome Biology
Subjects:
Expression quantitative trait loci (eQTLs)
Single cell RNA-sequencing (scRNA-seq)
Induced pluripotent stem cells (iPSCs)
Online Access:https://doi.org/10.1186/s13059-021-02293-3

Internet

https://doi.org/10.1186/s13059-021-02293-3

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