Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making

Migrating cells tune their energy utilization in response to their microenvironment, but how cellular energetics direct navigation remains unclear. Here, the authors report that energetic costs for motility, regulated by cell mechanics and confinement, predict the probability of migration choice.

Bibliographic Details
Main Authors: Matthew R. Zanotelli, Aniqua Rahman-Zaman, Jacob A. VanderBurgh, Paul V. Taufalele, Aadhar Jain, David Erickson, Francois Bordeleau, Cynthia A. Reinhart-King
Format: Article
Language:English
Published: Nature Publishing Group 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12155-z