Injectable hybrid system for strontium local delivery promotes bone regeneration in a rat critical-sized defect model

Abstract Strontium (Sr) has been described as having beneficial influence in bone strength and architecture. However, negative systemic effects have been reported on oral administration of Sr ranelate, leading to strict restrictions in clinical application. We hypothesized that local delivery of Sr...

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Bibliographic Details
Main Authors: Ana Henriques Lourenço, Nuno Neves, Cláudia Ribeiro-Machado, Susana R. Sousa, Meriem Lamghari, Cristina C. Barrias, Abel Trigo Cabral, Mário A. Barbosa, Cristina C. Ribeiro
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-04866-4