The induction of microRNA-16 in colon cancer cells by protein arginine deiminase inhibition causes a p53-dependent cell cycle arrest.

The induction of microRNA-16 in colon cancer cells by protein arginine deiminase inhibition causes a p53-dependent cell cycle arrest.

Protein Arginine Deiminases (PADs) catalyze the post-translational conversion of peptidyl-Arginine to peptidyl-Citrulline in a calcium-dependent, irreversible reaction. Evidence is emerging that PADs play a role in carcinogenesis. To determine the cancer-associated functional implications of PADs, w...

Full description

Bibliographic Details
Main Authors: Xiangli Cui, Erin E Witalison, Alena P Chumanevich, Alexander A Chumanevich, Deepak Poudyal, Venkataraman Subramanian, Aaron J Schetter, Curtis C Harris, Paul R Thompson, Lorne J Hofseth
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3538596?pdf=render

Internet

http://europepmc.org/articles/PMC3538596?pdf=render

Similar Items