A Herpesviral induction of RAE-1 NKG2D ligand expression occurs through release of HDAC mediated repression

A Herpesviral induction of RAE-1 NKG2D ligand expression occurs through release of HDAC mediated repression

Natural Killer (NK) cells are essential for control of viral infection and cancer. NK cells express NKG2D, an activating receptor that directly recognizes NKG2D ligands. These are expressed at low level on healthy cells, but are induced by stresses like infection and transformation. The physiologica...

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Bibliographic Details
Main Authors: Trever T Greene, Maria Tokuyama, Giselle M Knudsen, Michele Kunz, James Lin, Alexander L Greninger, Victor R DeFilippis, Joseph L DeRisi, David H Raulet, Laurent Coscoy
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-11-01
Series:eLife
Subjects:
NK cells
NKG2D
histone deacetylase
herpesviruses
NKG2D ligands
CK2
Online Access:https://elifesciences.org/articles/14749

Internet

https://elifesciences.org/articles/14749

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