Nav1.8 neurons are involved in limiting acute phase responses to dietary fat

Nav1.8 neurons are involved in limiting acute phase responses to dietary fat

Objective and methods: Metabolic viscera and their vasculature are richly innervated by peripheral sensory neurons. Here, we examined the metabolic and inflammatory profiles of mice with selective ablation of all Nav1.8-expressing primary afferent neurons. Results: While mice lacking sensory neurons...

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Bibliographic Details
Main Authors: Swalpa Udit, Michael Burton, Joseph M. Rutkowski, Syann Lee, Angie L. Bookout, Philipp E. Scherer, Joel K. Elmquist, Laurent Gautron
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Molecular Metabolism
Subjects:
Deafferentation
Diphtheria toxin
Energy homeostasis
Nodose ganglion
Inflammation
Obesity
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877817304969

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http://www.sciencedirect.com/science/article/pii/S2212877817304969

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