The diketopiperazine-fused tetrahydro-β-carboline scaffold as a model peptidomimetic with an unusual α-turn secondary structure

The diketopiperazine-fused tetrahydro-β-carboline scaffold as a model peptidomimetic with an unusual α-turn secondary structure

Aiming at restricting the conformational freedom of tryptophan-containing peptide ligands, we designed a THBC (tetrahydro-β-carboline)-DKP (diketopiperazine)-based peptidomimetic scaffold capable of arranging in an unusual α-turn conformation. The synthesis is based on a diastereoselective Pictet–Sp...

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Bibliographic Details
Main Authors: Francesco Airaghi, Andrea Fiorati, Giordano Lesma, Manuele Musolino, Alessandro Sacchetti, Alessandra Silvani
Format: Article
Language:English
Published: Beilstein-Institut 2013-01-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
α-turn
conformational analysis
diketopiperazine
peptidomimetics
tetrahydro-β-carboline
Online Access:https://doi.org/10.3762/bjoc.9.17

Internet

https://doi.org/10.3762/bjoc.9.17

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