Generalizing Terwilliger's likelihood approach: a new score statistic to test for genetic association

<p>Abstract</p> <p>Background:</p> <p>In this paper, we propose a one degree of freedom test for association between a candidate gene and a binary trait. This method is a generalization of Terwilliger's likelihood ratio statistic and is especially powerful for the...

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Bibliographic Details
Main Authors: Hsu Li, Helmer Quinta, de Visser Marieke CH, Uitte de Willige Shirley, el Galta Rachid, Houwing-Duistermaat Jeanine J
Format: Article
Language:English
Published: BMC 2007-09-01
Series:BMC Genetics
Online Access:http://www.biomedcentral.com/1471-2156/8/63