The stability of complement-mediated bactericidal activity in human serum against Salmonella.

The complement cascade includes heat-labile proteins and care is required when handling serum in order to preserve its functional integrity. We have previously used a whole human serum bactericidal assay to show that antibody and an intact complement system are required in blood for killing of invas...

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Bibliographic Details
Main Authors: Colette M O'Shaughnessy, Adam F Cunningham, Calman A Maclennan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23145102/?tool=EBI