CD8+ T-cell Immune Evasion Enables Oncolytic Virus Immunotherapy

CD8+ T-cell Immune Evasion Enables Oncolytic Virus Immunotherapy

Although counteracting innate defenses allows oncolytic viruses (OVs) to better replicate and spread within tumors, CD8+ T-cells restrict their capacity to trigger systemic anti-tumor immune responses. Herpes simplex virus-1 (HSV-1) evades CD8+ T-cells by producing ICP47, which limits immune recogni...

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Bibliographic Details
Main Authors: Aldo Pourchet, Steven R. Fuhrmann, Karsten A. Pilones, Sandra Demaria, Alan B. Frey, Matthew Mulvey, Ian Mohr
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:EBioMedicine
Subjects:
Oncolytic virus
Immunotherapy
TAP inhibitor
CD8+ T-cell immune evasion
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416300184

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http://www.sciencedirect.com/science/article/pii/S2352396416300184

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