Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer

Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer

Abstract Introduction Glutaminase inhibitors target cancer cells by blocking the conversion of glutamine to glutamate, thereby potentially interfering with anaplerosis and synthesis of amino acids and glutathione. The drug CB-839 has shown promising effects in preclinical experiments and is currentl...

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Bibliographic Details
Main Authors: Maria T. Grinde, Bylgja Hilmarsdottir, Hanna Maja Tunset, Ida Marie Henriksen, Jana Kim, Mads H. Haugen, Morten Beck Rye, Gunhild M. Mælandsmo, Siver A. Moestue
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Breast Cancer Research
Subjects:
13C MRS
Aldehyde dehydrogenase 18 family member A1 (ALDH18A1)
Cancer treatment
CB-839
Gene expression analysis
Glutaminase
Online Access:http://link.springer.com/article/10.1186/s13058-019-1141-0

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http://link.springer.com/article/10.1186/s13058-019-1141-0

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