Depolarizing GABA Transmission Restrains Activity-Dependent Glutamatergic Synapse Formation in the Developing Hippocampal Circuit

Depolarizing GABA Transmission Restrains Activity-Dependent Glutamatergic Synapse Formation in the Developing Hippocampal Circuit

γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mature brain but has the paradoxical property of depolarizing neurons during early development. Depolarization provided by GABAA transmission during this early phase regulates neural stem cell proliferation, neural migration,...

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Bibliographic Details
Main Authors: Christopher K. Salmon, Horia Pribiag, Claire Gizowski, W. Todd Farmer, Scott Cameron, Emma V. Jones, Vivek Mahadevan, Charles W. Bourque, David Stellwagen, Melanie A. Woodin, Keith K. Murai
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
synapse formation
hippocampus
GABA transmission
dendritic spines
chloride homeostasis
KCC2
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00036/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2020.00036/full

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