Depolarizing GABA Transmission Restrains Activity-Dependent Glutamatergic Synapse Formation in the Developing Hippocampal Circuit

Depolarizing GABA Transmission Restrains Activity-Dependent Glutamatergic Synapse Formation in the Developing Hippocampal Circuit

γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mature brain but has the paradoxical property of depolarizing neurons during early development. Depolarization provided by GABAA transmission during this early phase regulates neural stem cell proliferation, neural migration,...

Full description

Bibliographic Details
Main Authors:	Christopher K. Salmon, Horia Pribiag, Claire Gizowski, W. Todd Farmer, Scott Cameron, Emma V. Jones, Vivek Mahadevan, Charles W. Bourque, David Stellwagen, Melanie A. Woodin, Keith K. Murai
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-02-01
Series:	Frontiers in Cellular Neuroscience
Subjects:	synapse formation hippocampus GABA transmission dendritic spines chloride homeostasis KCC2
Online Access:	https://www.frontiersin.org/article/10.3389/fncel.2020.00036/full

Similar Items

Enhanced synaptic activity and epileptiform events in the embryonic Kcc2 deficient hippocampus
by: Ilgam eKhalilov, et al.
Published: (2011-11-01)

A Computational Study of Astrocytic GABA Release at the Glutamatergic Synapse: EAAT-2 and GAT-3 Coupled Dynamics
by: Bronac Flanagan, et al.
Published: (2021-07-01)

Expression of Neurofilament Subunits at Neocortical Glutamatergic and GABAergic Synapses
by: Luca Bragina, et al.
Published: (2018-09-01)

Disinhibition-Mediated LTP in the Hippocampus is Synapse Specific
by: Jake eOrmond, et al.
Published: (2011-09-01)

The role of GABA in the regulation of GnRH neurons
by: Miho eWatanabe, et al.
Published: (2014-11-01)

Coordinated Plasticity among Glutamatergic and GABAergic Neurons and Synapses in the Barrel Cortex Is Correlated to Learning Efficiency
by: Xin Zhao, et al.
Published: (2017-07-01)

Comprehensive Analysis of GABA<sub>A</sub>-A1R Developmental Alterations in Rett Syndrome: Setting the Focus for Therapeutic Targets in the Time Frame of the Disease
by: Alfonso Oyarzabal, et al.
Published: (2020-01-01)

Spike-timing dependent plasticity in inhibitory circuits
by: Karri P Lamsa, et al.
Published: (2010-06-01)

Contrôle de l'homéostasie du chlore par la leptine dans l'hippocampe : une nouvelle fonction neurotrophique pour un facteur périphérique
by: Dumon, Camille
Published: (2017)

Régulation post traductionnelle du co-transporteur potassium-chlorure KCC2
by: Friedel, Perrine
Published: (2014)

Neto2-null mice have impaired GABAergic inhibition and are susceptible to seizures
by: Vivek eMahadevan, et al.
Published: (2015-09-01)

Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition
by: Vivek Mahadevan, et al.
Published: (2017-10-01)

Building up the inhibitory synapse
by: Enrico eCherubini, et al.
Published: (2013-01-01)

Dopamine and Serotonin-Induced Modulation of GABAergic and Glutamatergic Transmission in the Striatum and Basal Forebrain
by: Toshihiko Momiyama, et al.
Published: (2017-05-01)

The small GTPase ARF6 regulates GABAergic synapse development
by: Hyeonho Kim, et al.
Published: (2020-01-01)

Plasticité GABAergique et épilepsie : focus sur le proBDNF
by: Riffault, Baptiste
Published: (2016)

Extracellular Metalloproteinases in the Plasticity of Excitatory and Inhibitory Synapses
by: Grzegorz Wiera, et al.
Published: (2021-08-01)

Thyroid hormone-dependent development of early cortical networks: Temporal specificity and the contribution of trkB and mTOR pathways
by: Sören eWesterholz, et al.
Published: (2013-08-01)

Development and regulation of chloride homeostasis in the central nervous system
by: Miho eWatanabe, et al.
Published: (2015-09-01)

The Chloride Homeostasis of CA3 Hippocampal Neurons Is Not Altered in Fully Symptomatic Mepc2-null Mice
by: Yasmine Belaïdouni, et al.
Published: (2021-09-01)

Molecular Characterization of GABA-A Receptor Subunit Diversity within Major Peripheral Organs and Their Plasticity in Response to Early Life Psychosocial Stress
by: Ethan A. Everington, et al.
Published: (2018-02-01)

Commentary: GABA Depolarizes Immature Neurons and Inhibits Network Activity in the Neonatal Neocortex In vivo
by: Yuri eZilberter
Published: (2015-12-01)

PLASMA MEMBRANE TRANSPORTERS GAT-1 AND GAT-3 CONTRIBUTE TO HETEROGENEITY OF GABAERGIC SYNAPSES IN NEOCORTEX
by: Marcello eMelone, et al.
Published: (2014-07-01)

The adipocyte hormone leptin sets the emergence of hippocampal inhibition in mice
by: Camille Dumon, et al.
Published: (2018-08-01)

Leptin down-regulates KCC2 activity and controls chloride homeostasis in the neonatal rat hippocampus
by: Camille Dumon, et al.
Published: (2020-11-01)

Current view on the functional regulation of the neuronal K+-Cl- cotransporter KCC2
by: Igor eMedina, et al.
Published: (2014-02-01)

Stress-induced plasticity of GABAergic inhibition
by: Jamie eMaguire
Published: (2014-06-01)

The Synapse as a Central Target for Neurodevelopmental Susceptibility to Pesticides
by: Aimee Vester, et al.
Published: (2016-08-01)

Distinct Translaminar Glutamatergic Circuits to GABAergic Interneurons in the Neonatal Auditory Cortex
by: Rongkang Deng, et al.
Published: (2017-05-01)

Régulation du cycle vésiculaire et de l’approvisionnement en GABA des interneurones de l’hippocampe en fonction de l’activité
by: Bonet, Laurine
Published: (2016)

Developmental Regulation of KCC2 Phosphorylation Has Long-Term Impacts on Cognitive Function
by: Yvonne E. Moore, et al.
Published: (2019-07-01)

Subplate neurons: crucial regulators of cortical development and plasticity
by: Patrick O Kanold
Published: (2009-08-01)

Regulatory domain or CpG site variation in SLC12A5, encoding the chloride transporter KCC2, in human autism and schizophrenia
by: Nancy D Merner, et al.
Published: (2015-10-01)

Deletion of the Na-K-2Cl cotransporter NKCC1 results in a more severe epileptic phenotype in the intrahippocampal kainate mouse model of temporal lobe epilepsy
by: Philip Hampel, et al.
Published: (2021-05-01)

Brain injury impairs dentate gyrus inhibitory efficacy
by: David P. Bonislawski, et al.
Published: (2007-01-01)

Preserved Function of Afferent Parvalbumin-Positive Perisomatic Inhibitory Synapses of Dentate Granule Cells in Rapidly Kindled Mice
by: Marita G. Hansen, et al.
Published: (2018-01-01)

Genetic Deletion of GABAA Receptors Reveals Distinct Requirements of Neurotransmitter Receptors for GABAergic and Glutamatergic Synapse Development
by: Jingjing Duan, et al.
Published: (2019-06-01)

Mechanism of BDNF Modulation in GABAergic Synaptic Transmission in Healthy and Disease Brains
by: Christophe Porcher, et al.
Published: (2018-08-01)

A prolonged experimental febrile seizure results in motor map reorganization in adulthood
by: Aylin Y. Reid, et al.
Published: (2012-02-01)

Gephyrin-Lacking PV Synapses on Neocortical Pyramidal Neurons
by: Dika A. Kuljis, et al.
Published: (2021-09-01)