Validation of an HPLC–MS/MS Method for the Determination of Plasma Ticagrelor and Its Active Metabolite Useful for Research and Clinical Practice

Validation of an HPLC–MS/MS Method for the Determination of Plasma Ticagrelor and Its Active Metabolite Useful for Research and Clinical Practice

Ticagrelor is an antiplatelet agent which is extensively metabolized in an active metabolite: AR-C124910XX. Ticagrelor antagonizes P2Y12 receptors, but recently, this effect on the central nervous system has been linked to the development of dyspnea. Ticagrelor-related dyspnea has been linked to per...

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Bibliographic Details
Main Authors: Jennifer Lagoutte-Renosi, Bernard Royer, Vahideh Rabani, Siamak Davani
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Molecules
Subjects:
ticagrelor
antiplatelet agents
high performance liquid chromatography
tandem mass spectrometry
adverse events
therapeutic drug monitoring
Online Access:https://www.mdpi.com/1420-3049/26/2/278

Internet

https://www.mdpi.com/1420-3049/26/2/278

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