A Microphysiological Approach to Evaluate Effectors of Intercellular Hedgehog Signaling in Development

A Microphysiological Approach to Evaluate Effectors of Intercellular Hedgehog Signaling in Development

Paracrine signaling in the tissue microenvironment is a central mediator of morphogenesis, and modeling this dynamic intercellular activity in vitro is critical to understanding normal and abnormal development. For example, Sonic Hedgehog (Shh) signaling is a conserved mechanism involved in multiple...

Full description

Bibliographic Details
Main Authors: Brian P. Johnson, Ross A. Vitek, Molly M. Morgan, Dustin M. Fink, Tyler G. Beames, Peter G. Geiger, David J. Beebe, Robert J. Lipinski
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
gene environment interaction
chemical screening
paracrine signaling
cleft lip and palate
embryonic morphogenesis
epithelial mesenchymal cross-talk
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.621442/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.621442/full

Similar Items