Joint MiRNA/mRNA expression profiling reveals changes consistent with development of dysfunctional corpus luteum after weight gain.

Joint MiRNA/mRNA expression profiling reveals changes consistent with development of dysfunctional corpus luteum after weight gain.

Obese women exhibit decreased fertility, high miscarriage rates and dysfunctional corpus luteum (CL), but molecular mechanisms are poorly defined. We hypothesized that weight gain induces alterations in CL gene expression. RNA sequencing was used to identify changes in the CL transcriptome in the ve...

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Bibliographic Details
Main Authors: Andrew P Bradford, Kenneth Jones, Katerina Kechris, Justin Chosich, Michael Montague, Wesley C Warren, Margaret C May, Zain Al-Safi, Satu Kuokkanen, Susan E Appt, Alex J Polotsky
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4530955?pdf=render

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http://europepmc.org/articles/PMC4530955?pdf=render

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