Identification and Validation of Loa loa Microfilaria-Specific Biomarkers: a Rational Design Approach Using Proteomics and Novel Immunoassays

Immunoassays are currently needed to quantify Loa loa microfilariae (mf). To address this need, we have conducted proteomic and bioinformatic analyses of proteins present in the urine of a Loa mf-infected patient and used this information to identify putative biomarkers produced by L. loa mf. In tot...

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Bibliographic Details
Main Authors: Papa M. Drame, Zhaojing Meng, Sasisekhar Bennuru, Jesica A. Herrick, Timothy D. Veenstra, Thomas B. Nutman
Format: Article
Language:English
Published: American Society for Microbiology 2016-02-01
Series:mBio
Online Access:http://mbio.asm.org/cgi/content/full/7/1/e02132-15