Levetiracetam as an alternative to phenytoin for second-line emergency treatment of children with convulsive status epilepticus: the EcLiPSE RCT

Levetiracetam as an alternative to phenytoin for second-line emergency treatment of children with convulsive status epilepticus: the EcLiPSE RCT

Background: Convulsive status epilepticus is the most common neurological emergency in children. Its management is important to avoid or minimise neurological morbidity and death. The current first-choice second-line drug is phenytoin (Epanutin, Pfizer Inc., New York, NY, USA), for which there is no...

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Main Authors: Richard E Appleton, Naomi EA Rainford, Carrol Gamble, Shrouk Messahel, Amy Humphreys, Helen Hickey, Kerry Woolfall, Louise Roper, Joanne Noblet, Elizabeth Lee, Sarah Potter, Paul Tate, Nadia Al Najjar, Anand Iyer, Vicki Evans, Mark D Lyttle
Format: Article
Language:English
Published: NIHR Journals Library 2020-11-01
Series:Health Technology Assessment
Subjects:
status epilepticus
convulsive
paediatric
epilepsy
seizure
levetiracetam
phenytoin
randomised
tria
Online Access:https://doi.org/10.3310/hta24580

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