GLP-1 Analog Liraglutide Improves Vascular Function in Polymicrobial Sepsis by Reduction of Oxidative Stress and Inflammation

GLP-1 Analog Liraglutide Improves Vascular Function in Polymicrobial Sepsis by Reduction of Oxidative Stress and Inflammation

Sepsis causes high mortality in the setting of septic shock. LEADER and other trials revealed cardioprotective and anti-inflammatory properties of glucagon-like peptide-1 (GLP-1) analogs like liraglutide (Lira). We previously demonstrated improved survival in lipopolysaccharide (LPS)-induced endotox...

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Bibliographic Details
Main Authors: Johanna Helmstädter, Karin Keppeler, Franziska Aust, Leonie Küster, Katie Frenis, Konstantina Filippou, Ksenija Vujacic-Mirski, Simeon Tsohataridis, Sanela Kalinovic, Swenja Kröller-Schön, Matthias Oelze, Markus Bosmann, Thomas Münzel, Andreas Daiber, Sebastian Steven
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Antioxidants
Subjects:
glucagon-like peptide-1 (GLP-1)
incretins
liraglutide
peritoneal and polymicrobial sepsis
cecal ligation and puncture (CLP)
endothelial dysfunction
Online Access:https://www.mdpi.com/2076-3921/10/8/1175

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https://www.mdpi.com/2076-3921/10/8/1175

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