Genomic HIV RNA induces innate immune responses through RIG-I-dependent sensing of secondary-structured RNA.

Genomic HIV RNA induces innate immune responses through RIG-I-dependent sensing of secondary-structured RNA.

Innate immune responses have recently been appreciated to play an important role in the pathogenesis of HIV infection. Whereas inadequate innate immune sensing of HIV during acute infection may contribute to failure to control and eradicate infection, persistent inflammatory responses later during i...

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Bibliographic Details
Main Authors: Randi K Berg, Jesper Melchjorsen, Johanna Rintahaka, Elisabeth Diget, Stine Søby, Kristy A Horan, Robert J Gorelick, Sampsa Matikainen, Carsten S Larsen, Lars Ostergaard, Søren R Paludan, Trine H Mogensen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3250430?pdf=render

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http://europepmc.org/articles/PMC3250430?pdf=render

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