Structure of the membrane anchor of pestivirus glycoprotein E(rns), a long tilted amphipathic helix.

Structure of the membrane anchor of pestivirus glycoprotein E(rns), a long tilted amphipathic helix.

E(rns) is an essential virion glycoprotein with RNase activity that suppresses host cellular innate immune responses upon being partially secreted from the infected cells. Its unusual C-terminus plays multiple roles, as the amphiphilic helix acts as a membrane anchor, as a signal peptidase cleavage...

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Bibliographic Details
Main Authors: Daniel Aberle, Claudia Muhle-Goll, Jochen Bürck, Moritz Wolf, Sabine Reißer, Burkhard Luy, Wolfgang Wenzel, Anne S Ulrich, Gregor Meyers
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-02-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24586172/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24586172/?tool=EBI

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