Transient Changes of Metabolism at The Pronuclear Stage in Mice Influences Skeletal Muscle Phenotype in Adulthood

Transient Changes of Metabolism at The Pronuclear Stage in Mice Influences Skeletal Muscle Phenotype in Adulthood

Skeletal muscle has a remarkable plasticity, and its phenotype is strongly influenced by hormones, transcription factors, and physical activity. However, whether skeletal phenotype can be oriented or not during early embryonic stages has never been investigated. Here, we report that pyruvate as the...

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Bibliographic Details
Main Authors: Christelle Bertrand-Gaday, Martine Letheule, Emilie Blanchet, Barbara Vernus, Laurence Pessemesse, Amélie Bonnet-Garnier, Anne Bonnieu, François Casas
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
embryo
metabolic reprogramming
mitochondria
skeletal Muscle
epigenetic
Online Access:https://www.mdpi.com/1422-0067/21/19/7203

Internet

https://www.mdpi.com/1422-0067/21/19/7203

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