Discovery and Optimization of Selective Inhibitors of Meprin α (Part II)

Discovery and Optimization of Selective Inhibitors of Meprin α (Part II)

Meprin α is a zinc metalloproteinase (metzincin) that has been implicated in multiple diseases, including fibrosis and cancers. It has proven difficult to find small molecules that are capable of selectively inhibiting meprin a, or its close relative meprin b, over numerous other metzincins which, i...

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Bibliographic Details
Main Authors: Chao Wang, Juan Diez, Hajeung Park, Timothy P. Spicer, Louis D. Scampavia, Christoph Becker-Pauly, Gregg B. Fields, Dmitriy Minond, Thomas D. Bannister
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Pharmaceuticals
Subjects:
meprin α
meprin β
zinc metalloproteinase
medicinal chemistry
probe development
Online Access:https://www.mdpi.com/1424-8247/14/3/197

Internet

https://www.mdpi.com/1424-8247/14/3/197

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