Synthesis, docking study and biological evaluation of some new thiourea derivatives bearing benzenesulfonamide moiety

Synthesis, docking study and biological evaluation of some new thiourea derivatives bearing benzenesulfonamide moiety

Abstract Background A series of novel N-(2, 6-dimethoxypyrimidin-4-yl)-4-(3-(aryl)thioureido) benzenesulfonamides 3a–t was synthesized by the addition of N-(2,6-dimethoxypyrimidin-4-yl)-4-isothiocyanatobenzenesulfonamide 2 to the appropriate aromatic amine. The structures of the synthesized compound...

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Bibliographic Details
Main Authors: Mostafa M. Ghorab, Mohamed S. A. El-Gaby, Aiten M. Soliman, Mansour S. Alsaid, Marwa M. Abdel-Aziz, Mahmoud M. Elaasser
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Chemistry Central Journal
Subjects:
Thiourea
Sulfonamides
Structure–activity relationship
Antimycobacterial
Online Access:http://link.springer.com/article/10.1186/s13065-017-0271-7

Internet

http://link.springer.com/article/10.1186/s13065-017-0271-7

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