CDK5RAP3 inhibits angiogenesis in gastric neuroendocrine carcinoma by modulating AKT/HIF-1α/VEGFA signaling

CDK5RAP3 inhibits angiogenesis in gastric neuroendocrine carcinoma by modulating AKT/HIF-1α/VEGFA signaling

Abstract Background Angiogenesis plays critical roles in the progression and metastasis of malignant tumors. Gastric neuroendocrine carcinoma is an uncommon stomach cancer that is rich in blood vessels and exhibits highly malignant biological behavior with a poor prognosis. The role of CDK5RAP3 in G...

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Bibliographic Details
Main Authors: Jian-Xian Lin, Xiong-Feng Weng, Xin-Sheng Xie, Ning-Zi Lian, Sheng-Liang Qiu, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ying-Hong Yang, Si-Jia Liu, Min Hu, Yi-Ke Lin, Chang-Ming Huang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Cancer Cell International
Subjects:
CDK5RAP3
VEGFA
Angiogenesis
Gastric neuroendocrine carcinoma
Online Access:http://link.springer.com/article/10.1186/s12935-019-0997-5

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http://link.springer.com/article/10.1186/s12935-019-0997-5

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