Regulation of Apoptosis and Radiation Sensitization in Lung Cancer Cells via the Sirt1/NF-κB/Smac Pathway

Regulation of Apoptosis and Radiation Sensitization in Lung Cancer Cells via the Sirt1/NF-κB/Smac Pathway

Background/Aims: SirT1, a conserved NAD+-dependent deacetylase, has been implicated in modulating cell survival and stress responses, and it appears to play an important role in tumorigenesis and cancer resistance to chemoradiotherapy. The mechanism of SirT1 in cancer chemoradiotherapy remains to be...

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Bibliographic Details
Main Authors: Kaihua Ji, Xiaohui Sun, Yang Liu, Liqing Du, Yan Wang, Ningning He, Jinhan Wang, Chang Xu, Qiang Liu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
Sirt1
NF-κB
Smac
Apoptosis
Radiation sensitization
Online Access:https://www.karger.com/Article/FullText/491730

Internet

https://www.karger.com/Article/FullText/491730

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