Molecular techniques for the personalised management of patients with chronic myeloid leukaemia

Chronic myeloid leukemia (CML) is the paradigm for targeted cancer therapy. RT-qPCR is the gold standard for monitoring response to tyrosine kinase-inhibitor (TKI) therapy based on the reduction of blood or bone marrow BCR-ABL1. Some patients with CML and very low or undetectable levels of BCR-ABL1...

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Bibliographic Details
Main Authors: Mary Alikian, Robert Peter Gale, Jane F Apperley, Letizia Foroni
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Biomolecular Detection and Quantification
Subjects:
CML
MRD
NGS
Online Access:http://www.sciencedirect.com/science/article/pii/S2214753517300013