Detection of Germline Mutations in a Cohort of 139 Patients with Bilateral Breast Cancer by Multi-Gene Panel Testing: Impact of Pathogenic Variants in Other Genes beyond <i>BRCA1/2</i>

Detection of Germline Mutations in a Cohort of 139 Patients with Bilateral Breast Cancer by Multi-Gene Panel Testing: Impact of Pathogenic Variants in Other Genes beyond <i>BRCA1/2</i>

Patients with unilateral breast cancer (UBC) have an increased risk of developing bilateral breast cancer (BBC). The annual risk of contralateral BC is about 0.5%, but increases by up to 3% in <i>BRCA1</i> or <i>BRCA2 pathogenic variant</i> (PV) carriers. Our study was aimed...

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Bibliographic Details
Main Authors: Daniele Fanale, Lorena Incorvaia, Clarissa Filorizzo, Marco Bono, Alessia Fiorino, Valentina Calò, Chiara Brando, Lidia Rita Corsini, Nadia Barraco, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
<i>ATM</i>
<i>BRCA1</i>
<i>BRCA2</i>
breast cancer
bilateral breast cancer
<i>CHECK2</i>
Online Access:https://www.mdpi.com/2072-6694/12/9/2415

Internet

https://www.mdpi.com/2072-6694/12/9/2415

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