Lipocalin-2 (Lcn-2) Attenuates Polymicrobial Sepsis with LPS Preconditioning (LPS Tolerance) in FcGRIIb Deficient Lupus Mice

Lipocalin-2 (Lcn-2) Attenuates Polymicrobial Sepsis with LPS Preconditioning (LPS Tolerance) in FcGRIIb Deficient Lupus Mice

In patients with active lupus, spontaneous endotoxemia and possibly tolerance to lipopolysaccharide (LPS) is a potentially adverse complication. Similarly, previous reports have demonstrated that FcGRIIb deficient mice (FcGRIIb-/-; a lupus mouse model) are susceptible to LPS tolerance-induced decrea...

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Bibliographic Details
Main Authors: Thunnicha Ondee, Joseph Gillen, Peerapat Visitchanakun, Poorichaya Somparn, Jiraphorn Issara-Amphorn, Cong Dang Phi, Wiwat Chancharoenthana, Devikala Gurusamy, Aleksandra Nita-Lazar, Asada Leelahavanichkul
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cells
Subjects:
Fc gamma receptor IIb deficient macrophages
lupus
Lipocalin 2
neutrophil gelatinase-associated lipocalin (NGAL)
Online Access:https://www.mdpi.com/2073-4409/8/9/1064

Internet

https://www.mdpi.com/2073-4409/8/9/1064

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