Generation of a Urine-Derived Ips Cell Line from a Patient with a Ventricular Septal Defect and Heart Failure and the Robust Differentiation of These Cells to Cardiomyocytes via Small Molecules

Generation of a Urine-Derived Ips Cell Line from a Patient with a Ventricular Septal Defect and Heart Failure and the Robust Differentiation of These Cells to Cardiomyocytes via Small Molecules

Background/Aims: Ventricular septal defects (VSDs) are one of the most common types of congenital heart malformations. Volume overload resulting from large VSDs can lead to heart failure (HF) and constitutes a major cause of pediatric HF with a series of often-fatal consequences. The etiology of VSD...

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Bibliographic Details
Main Authors: Yinyin Cao, Jin Xu, Junxiang Wen, Xiaojing Ma, Fang Liu, Yang Li, Weicheng Chen, Liqun Sun, Yao Wu, Shuolin Li, Jian Li, Guoying Huang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-10-01
Series:Cellular Physiology and Biochemistry
Subjects:
Ventricular septal defect
Heart failure
Urine-derived cells
Induced pluripotent stem cells
Differentiation
Cardiomyocytes
Small molecules
Autophagy
Online Access:https://www.karger.com/Article/FullText/494167

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https://www.karger.com/Article/FullText/494167

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