Potent prion-like behaviors of pathogenic α-synuclein and evaluation of inactivation methods

Potent prion-like behaviors of pathogenic α-synuclein and evaluation of inactivation methods

Abstract The concept that abnormal protein aggregates show prion-like propagation between cells has been considered to explain the onset and progression of many neurodegenerative diseases. Indeed, both synthetic amyloid-like fibrils and pathogenic proteins extracted from patients’ brains induce self...

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Bibliographic Details
Main Authors: Airi Tarutani, Tetsuaki Arai, Shigeo Murayama, Shin-ichi Hisanaga, Masato Hasegawa
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Acta Neuropathologica Communications
Subjects:
α-Synuclein
Prion-like propagation
Seeds
α-Synucleinopathy
Strains
Inactivation
Online Access:http://link.springer.com/article/10.1186/s40478-018-0532-2

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http://link.springer.com/article/10.1186/s40478-018-0532-2

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