Distinct tryptophan catabolism and Th17/Treg balance in HIV progressors and elite controllers.

Distinct tryptophan catabolism and Th17/Treg balance in HIV progressors and elite controllers.

Tryptophan (Trp) catabolism into immunosuppressive kynurenine (Kyn) by indoleamine 2,3-dioxygenase (IDO) was previously linked to Th17/Treg differentiation and immune activation. Here we examined Trp catabolism and its impact on Th17/Treg balance in uninfected healthy subjects (HS) and a large cohor...

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Bibliographic Details
Main Authors: Mohammad-Ali Jenabian, Mital Patel, Ido Kema, Cynthia Kanagaratham, Danuta Radzioch, Paméla Thébault, Réjean Lapointe, Cécile Tremblay, Norbert Gilmore, Petronela Ancuta, Jean-Pierre Routy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3797729?pdf=render

Internet

http://europepmc.org/articles/PMC3797729?pdf=render

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